(Photo credit: Denis Poroy-Imagn Images)

Nico Hoerner tripled in the go-ahead run in the top of the 10th inning on Tuesday and the visiting Chicago Cubs handed the San Diego Padres their first home loss, 2-1.

With Dansby Swanson placed at second base as the automatic runner, Hoerner lined a 2-0 fastball from Yuki Matsui (0-1) to the gap in right-center, easily scoring Swanson. It capped a three-hit game for Hoerner.

Ryan Pressly (1-1) got the win with a 1-2-3 ninth and Caleb Thielbar earned his first save, retiring Luis Arraez on a fly ball to left with runners at the corners and two outs in San Diego's half of the 10th.

The outcome snapped the Padres' 11-game winning streak at Petco Park to start the season. San Diego carried a 15-game home winning streak into the game, dating back to last year.

Red Sox 7, Rays 4

Alex Bregman collected five hits, including two home runs, and drove in four runs to lead visiting Boston past Tampa Bay.

The Red Sox also received a two-run homer from Jarren Duran, who walked twice and scored twice. Boston starter Walker Buehler (2-1) permitted two runs on three hits in five innings. Aroldis Chapman struck out the only batter he faced to earn his fourth save.

Jonathan Aranda, who homered, and Jake Mangum each had two of the Rays' seven hits. Ryan Pepiot (1-2) went six innings and gave up six runs on nine hits.

Dodgers 6, Rockies 2

Will Smith hit a three-run home run in a four-run third inning and Tommy Edman had four hits as Los Angeles beat visiting Colorado amid the annual Jackie Robinson Day celebration.

Chris Taylor added an RBI single in the third inning for L.A., and Freddie Freeman added an RBI single in the eighth. Dodgers starter Landon Knack lasted 4 1/3 innings, giving up two runs on four hits. Rookie Jack Dreyer (2-0) had four strikeouts in 1 2/3 innings to earn the win.

Jacob Stallings hit a two-run double for the Rockies, who saw their losing streak reach five games. Colorado has scored five total runs during the skid. Ryan Feltner (0-1) gave up five runs on five hits with six walks in 2 2/3 innings.

Brewers 5, Tigers 0

Quinn Priester and four relievers combined on a one-hitter and Rhys Hoskins jump-started the offense with his first homer as Milwaukee ended a three-game skid with a win over visiting Detroit.

Priester (1-0), making his second start for the Brewers after being acquired from Boston this month, allowed just three walks over five hitless innings before Gleyber Torres produced a leadoff double in the sixth.

Tigers starter Jack Flaherty (1-1) allowed three runs on five hits in 4 2/3 innings.

Twins 6, Mets 3

Brooks Lee homered, Ryan Jeffers went 3-for-3 with two doubles, and Minnesota held on to beat New York in Minneapolis.

Harrison Bader added three hits, a stolen base and an RBI for Minnesota. Byron Buxton had two hits, two runs and a stolen base. Bailey Ober (1-1) allowed three runs on five hits in 6 1/3 innings.

Pete Alonso and Juan Soto each hit a solo home run for New York. Jesse Winker also drove in a run for the Mets, who lost for only the third time in their past 12 games. Tylor Megill (2-2) gave up four runs (two earned) on eight hits in five innings.

Reds 8, Mariners 4

Austin Hays belted a go-ahead three-run homer and drove in four in his Cincinnati debut to help rally the Reds past visiting Seattle.

Hays, who spent the first 16 games on the injured list, went 2-for-4 for the Reds, who won their fourth straight to move over .500 for the first time this season. Matt McLain walked three times and scored twice in his return from the injured list. Gavin Lux went 4-for-4 with two RBIs.

Dylan Moore drilled a pair of home runs and drove in four for the Mariners, who had their four-game win streak snapped. Seattle starter Luis Castillo (1-2), the former ace of the Reds, gave up six runs on seven hits in 4 1/3 innings.

Phillies 6, Giants 4

J.T. Realmuto and Bryce Harper each homered and drove in two runs as Philadelphia topped visiting San Francisco to even the four-game series at one win apiece.

Alec Bohm had the go-ahead hit for the Phillies, who had dropped four of their previous five games. Bryson Stott and Max Kepler chipped in two hits apiece in support of Jesus Luzardo, who allowed three runs and five hits over 5 1/3 innings.

Justin Verlander (0-1) remained winless in four starts for San Francisco, allowing four runs and eight hits over 5 2/3 innings. Casey Schmitt drove in two runs for the Giants, who were 4-1 in their previous five games.

Nationals 3, Pirates 0

Jake Irvin scattered three hits over seven shutout innings to help Washington beat host Pittsburgh.

James Wood hit a game-opening homer for the Nationals, who snapped a three-game losing streak. Jose Ferrer and Kyle Finnegan combined to allow one hit over the final two frames with Finnegan picking up his sixth save.

Pirates starter Mitch Keller (1-2) yielded three runs in six innings. Jack Suwinski recorded two of Pittsburgh's four hits.

Diamondbacks 10, Marlins 4

Corbin Carroll slugged a grand slam and drove in five runs, leading visiting Arizona to a win over Miami.

Geraldo Perdomo blasted a three-run homer and Josh Naylor hit a solo shot for the Diamondback, who have won three in a row. Merrill Kelly (3-1) struck out nine batters while allowing just three hits, one walk and one run in six innings.

Connor Gillispie (0-2) gave up eight runs on eight hits in five-plus innings as the Marlins' two-game winning streak ended.

Guardians 6, Orioles 3

Logan Allen held Baltimore to two hits across 5 2/3 scoreless innings as visiting Cleveland opened a three-game series with a victory.

Steven Kwan hit a two-run homer and drove in three runs and Angel Martinez had three hits as the Guardians picked up their sixth win in the past seven games. Allen (1-1) walked two and struck out six to produce his first victory since last June 20.

The Orioles lost for the fourth time in five games despite getting two hits apiece from Cedric Mullins, who homered, and Gunnar Henderson. Baltimore starter Charlie Morton (0-4) lasted five-plus innings and was charged with five runs on seven hits.

Athletics 12, White Sox 3

Tyler Soderstrom hit two homers and drove in a career-high six runs and Shea Langeliers also homered, doubled and drove in two runs to lead the visiting Athletics past Chicago.

Soderstrom took over the major league home run lead (eight) with his third multi-homer game of the season. Soderstrom and Langeliers each finished with three hits. Jeffrey Springs (3-1) threw five innings of three-run ball, and Mitch Spence tossed three shutout innings for his first career save.

Andrew Vaughn hit a three-run homer and Lenyn Sosa had two hits and a run for the White Sox. Sean Burke (1-3) allowed five runs on six hits over 3 1/3 innings.

Yankees 4, Royals 2

Jasson Dominguez highlighted a three-hit performance by hitting a bases-clearing double with two outs in the sixth inning, leading New York to a come-from-behind victory over visiting Kansas City.

In his 41st career game, Dominguez set a personal high with three RBIs. Max Fried (3-0) allowed two runs on five hits in 6 2/3 innings. Devin Williams pitched a perfect ninth for his third save.

Kansas City starter Michael Wacha (0-3) cruised through five innings with a 2-0 lead before the Yankees scored four in the sixth. Wacha was charged with three runs on four hits in 5 2/3 innings.

Rangers 4, Angels 0

Marcus Semien and Kyle Higashioka each drove in a run to back the pitching of Tyler Mahle and four relievers as Texas blanked Los Angeles in Arlington, Texas.

Mahle (3-0) struck out nine in six scoreless innings while allowing just three hits and two walks. The Rangers' Corey Seager and Kevin Pillar each had two hits.

Jorge Soler collected two of the Angels' five hits. Yusei Kikuchi (0-3) surrendered one run on three hits in six innings.

Blue Jays 6, Braves 3

Anthony Santander hit a three-run homer and Alan Roden cracked his first major league home run as Toronto defeated visiting Atlanta to even the three-game series at one win apiece.

Toronto starter Kevin Gausman (2-1) allowed two runs on six hits in six innings. Roden finished 2-for-3 as he added a third-inning double and came around to score.

Austin Riley, Matt Olson and Ozzie Albies hit solo home runs to account for the Braves' offense. Spencer Schwellenbach (1-1) yielded six runs on six hits in 4 2/3 innings.

Astros 2, Cardinals 0

Hunter Brown extended his consecutive scoreless inning streak to 17 innings as visiting Houston blanked St. Louis to knot a three-game interleague series.

Brown (2-1) worked six shutout innings for a second consecutive start. Jake Meyers, who recorded three hits, delivered an RBI single in the sixth inning, and Yordan Alvarez homered leading off the eighth. Josh Hader earned his fourth save with a perfect ninth inning.

Cardinals starter Erick Fedde (1-2) allowed one run on six hits in six innings.

--Field Level Media